From: 13/07/2017 to: 18/07/2017 ESMO-ESO Course on Medical Oncology for Medical Students, Valencia, Spain                                        From: 15/07/2017 to: 15/07/2017 Breast Cancer in Young Women: Joint DFCI-ESO Symposium, Boston, US                                        From: 28/08/2017 to: 08/09/2017 ESO-ESSO-ESTRO Multidisciplinary Course in Oncology for Medical Students, Antwerp, Belgium                                        From: 06/10/2017 to: 07/10/2017 Eastern Europe and Balkan Region Refresher Course on Breast Cancer, Krakow, Poland                                        From: 18/10/2017 to: 20/10/2017 4th Masterclass in Clinical Oncology, Tbilisi, Georgia                                        From: 18/10/2017 to: 18/10/2017 ESO Breast Cancer Observatory, Tehran, Iran                                        From: 27/10/2017 to: 28/10/2017 9th Clinical Oncology Update - Onkologia 2017, Krakow, Poland                                        From: 02/11/2017 to: 04/11/2017 ESO-ESMO Advanced Breast Cancer Fourth International Consensus Conference (ABC4), Lisbon, Portugal                                        From: 02/12/2017 to: 04/12/2017 ESO-ESMO-RCE Clinical Update on Rare Adult Solid Cancers, Milan, Italy                                        From: 15/12/2017 to: 18/12/2017 6th Arab and Southern European Countries Masterclass in Clinical Oncology, Limassol, Cyprus                                        From: 24/03/2018 to: 29/03/2018 17th ESO-ESMO Masterclass in Clinical Oncology, Nauen OT Groß Behnitz (Berlin area), Germany                                        From: 18/04/2018 to: 22/04/2018 4th ESO-ESMO Latin-American Masterclass in Clinical Oncology, Mexico City, Mexico                                        From: 6/10/2018 to: 8/10/2018 4th ESO-ESMO Breast Cancer in Young Women International Conference, Lugano, Switzerland

Curriculum

 

 

Attendance 1 

Module

Module
2

Module
3

Attendance 2

Module

Module
5

Attendance 3

Total 

Timeline

 2017
15-18 Mar

2017
Apr/Jun
3 months

2017
Jul/Aug
2 months

2017
Sept/Oct
2 months

2017
1-4 Nov

2017-2018
Nov/Jan
2.5 months

2018
Mid Jan/Mar
2.5 months

2018
24-28 Apr

13 months 

Content

 CCB only
+
St. Gallen
Breast Cancer
Conference
Vienna

Topic 1
Epidemiology
and
prevention,
biology and
clinical
trials



 Topic 2
Principles of
diagnostics,
DCIS, gene
predisposition



Topic 3
The breast
unit model
and LABC


CCB only
+
ABC3
Lisbon

Topic 4
Management of
early breast
cancer



Topic 5
Management
of advanced
breast cancer
male breast
cancer and
supportive
therapies



 

CCB stand-
alone seminar,
including
practical
training

+
Exam
Ulm

 

Workload

 25 hrs
In-person

25 units
75 hrs
Distance
learning
+ Module test

 14 units
42 hrs
Distance
learning
+ Module test

13 units
39 hrs
Distance
learning
+ Module test


25 hrs
In-person

25 units
75 hrs
Distance
learning
+ Module test 

25 units
75 hrs
Distance
learning
+ Module test 

25 hrs
In-person
+
Certificate
exam

75 hrs
In-person
+
306 hrs
Distance
learning

381 hrs

Credits

1 ECTS 

52 units - 156 hrs
 5 ECTS

1 ECTS 

50 units - 150 hrs
5 ECTS 

1 ECTS

13 ECTS 

  

The extensiveness of the Module’s programme is expressed in Units.

1 Unit equals to 3 hours of workload, consisting of a 30-minute lecture and 2,5 hours of additional reading.

For instance: 2 Units = 6 hours of workload = 60-minute lecture + 5 hours of additional reading.


  
 Seminar/Module  Topics 

Units 

Workload
hours 

ECTS 

Comment 

 Seminar 1:

 CCB

 St. Gallen
 BCC 2017
 Vienna,
 Austria


 

 

 

 





     
 Programme will follow


  
 Module 1:

 Epidemiology
 and prevention,
 biology and
 clinical trials
 Scientific Directors: Jack Cuzick, Olivia Pagani

25

75

--

 Test (50q) 

 Epidemiology and risk factors
 [Adam Brentnall]

1

3  
 Breast cancer prevention: Pharmaco-prevention
 [Jack Cuzick]

1

3  
 Breast cancer prevention: Lifestyle changes
 [Matti Rookus]

1

3  

 Pathology of invasive breast cancer
 [TBC]

1

3  
 Prognostic and predictive markers
 [Ivana Sestak]

1

3  
 Intratumor heterogeneity
 [Giancarlo Pruneri]

1

3  
 Mechanisms of signal transduction and resistance:
 - PI3K/AKT/mTOR pathway signaling,
 - Her2/ras/MAPK pathway signaling,
 - ER pathway
 - Cell cycle (e.g. CDKs)
 [Giuseppe Curigliano]

1 3  
 Inflammatory and breast cancer
 [Steven van Laere]
13  
 Pathology of rare breast cancer subtypes
 (medullary, apocrine, sarcomas, phyllodes, lymphoma)
 [Tibor Tot]
13  
 Molecular portraits of breast cancer, genomic and proteomics,
 risk of recurrence scores
 [John Martens]
26  
 Local relapse patterns
 [Louise Jones]
13  
 Dissemination and organ specific metastasis according to subtype
 [Roger Gomis]
13  
 Circulating tumor cells
 [Klaus Pantel]
13  
  Principles of clinical trials:
  - Design and interpretation
  - Design of biomarker driven neoadjuvant trials
 [Marc Buyse]

2

6  
 Biostatistics
 [Vincenzo Bagnardi]

2

6  
 Planning and performance of clinical trials
 (introduction into good clinical practice)
 [Benoit Aigret]
26  
 Management of a clinical trial database
 [Richard Ostler]
13  
 Transfer of study results into clinical practice
 [Bent Ejlertsen]
13  
 The challenge of translational research:
 - Integrating molecular biology within clinical trials [TBC]
 - Management of biobanks [Peter Riegman]
13  
 Major meta-analysis collaboration in breast cancer
 [Christina Davies]
26  
 Module 2:

 Principles of
 diagnostic,
 DCIS genetic
 predisposition
 Scientific Directors: Tibor Tot, Olivia Pagani

14

42

--

 test (28q) 

 Principles of standard diagnostics
 (mammography, ultrasound, MRI)
 [Katja Pinker]

2

6  
 New radiological techniques
 [Julia Camps Herrero]

1

3  
 Breast cancer screening
 [Nehmat Houssami]

1

3  
 Interventional radiology:
 - Limphoscintigraphy, ROLL
 - Mammotome, MRI-guided biopsy [Pietro Panizza]

1

3  
 Diagnostic challenges in young women and during pregnancy
 [Tanja Gagliardi]

1

3  
 To stage or not to stage:
 - Conventional staging
 - PET/CT
 [Elzbieta Senkus]

1

3  
 DCIS: Radiological assessment
 [Katja Pinker]

1

3  
 DCIS: Pathology classification and margins
 [Tibor Tot]

1

3  
 DCIS: Surgical challenges
 [Linda Wyld]

1

3  
 DCIS: The role of radiotherapy
 [Youlia Kirova]

1

3
  
 DCIS: The role of medical treatment
 [Mangesh Thorat]

1

3  
 Genetic predisposition assessment and management
 [Helen Hanson]

2

6
  

 Module 3:
  

 The breast unit
 model and its
 organizational
 aspect,
 multidisciplinary
 management of
 LABC

 Scientific Directors: Oreste Gentilini, Olivia Pagani13

39

--

 Test (26q)
 Principles of multidisciplinary treatment: The breast unit model
 [Christoph Thomssen]
13  
 Organizational aspects of breast units:
 Identifying key components of effective teams and being aware
 of the most recurrent team inefficiencies
 [Lorenza Marotti]

13  
 Organizational aspects of breast units:
 The leadership cycle – From vision to facts
 [Isabel Rubio]
13  
 Organizational aspects of breast units:
 Cost-effectiveness evaluations and budget considerations
 [Didier Verhoeven]
13  
 The role of international guidelines
 (San Gallen, NCCN, ESMO, Eusoma, AGO)
 [Fatima Cardoso]
26  
 Management of locally advanced and inflammatory breast cancer: 
 Indications and principles of multidisciplinary treatment
 planning and management
 [Marco Colleoni]
13  
 Principles of baseline diagnostics
 (mammography, ultrasound, MRI) and disease evaluation
 after neoadjuvant therapy
 [Laura Martincich]
13  
 Neoadjuvant systemic treatment
 (chemotherapy, targeted therapy and endocrine therapy)
 [Marco Colleoni]
39  
 Surgery after neoadjuvant therapy
 [Oreste Gentilini]
13  
 Radiotherapy after neoadjuvant therapy
 [David Krug]
13  
 Seminar 2:

 CCB

 ABC4 2017
 
Lisbon,
 Portugal
 

 

25
1
No exam
 Communiation Workshop
 [A Hoy and D. Manship, UK]

1
 
 The Epidemiology of ABC
 [O.Pagani, CH]
 
 0.75  
 The ABC Research agenda
 [G. Curigliano, IT]   
 
 0.75  
 Management of aBC in countries with limited resources
 [A. Eniu, RO]   
 
 0.75  
 Research priorities in elderly women
 [L. Biganzoli, IT]   
 
 0.75  
 Patients’ perspectives and needs
 [E. Papadopolous, CY]

0.75
 
 Treatment and research priorities in women with ABC and germline
 mutations [S. Paluch-Shimon, IL]
 
 0.75  
 Case Presentations   
 
 3.5  
 Advanced Breast Cancer Fourth International Consensus Conference
 Hours based on ABC3, TBC for ABC4

16
Regular CME
assigned by
ABC4

 Module 4:


 Management
 of early breast

 cancer

 Scientific Directors: Volkmar Müller, Olivia Pagani

25

75

--

 Test (50q) 

 Evolution of surgery: invasive disease
 [Peter Dubsky]

1

3  

 Evolution of surgery: How to define and manage positive margins
 [Peter Dubsky]

1

3  
 Evolution of surgery: Axillary staging and management
 [Thorsten Kühn]

1

3  
 Evolution of surgery: Skin and nipple sparing mastectomy
 [Antonio Toesca]

1

3  
 Evolution of surgery: Young women
 [Tibor Kovacs]

1

3  
 Principles of oncoplastic surgery
 [Maria João Cardoso]

1

3  
 New techniques in oncoplastic surgery: Lipofilling
 
[Maria João Cardoso]

1

3  
 Principles of radiotherapy for invasive early breast cancer:
 Radiotherapy after BCS
 [Frederick Wenz]

1

3  
 Principles of radiotherapy for invasive early breast cancer: PBI
 [Frederick Wenz]

1

3  
 Principles of radiotherapy for invasive early breast cancer:
 Radiotherapy after mastectomy and reconstruction
 [Roberto Orecchia]

1

3  
 Principles of radiotherapy for invasive early breast cancer:
 Loco-regional radiotherapy
 [Roberto Orecchia]

1

3  
 Principles of radiotherapy for invasive early breast cancer:
 Early and late toxicity of radiotherapy
 [Roberto Orecchia]

1

3  
 Adjuvant systemic therapies: Endocrine therapy
 [Olivia Pagani]

1

3  
 Adjuvant systemic therapies: Targeted therapy
 [Xavier Pivot]

1

3  
 Adjuvant systemic therapies: Chemotherapy
 [David Cameron]

1

3  
 Management of triple negative breast cancer
 [Sara Lopez-Tarruella]

1

3  
 Management of young women
 [Ann Partridge]

1

3  
 Management of elderly women
 [Matti Aapro]

1

3  
 Early and late toxicity of systemic therapy
 [Matti Aapro]

1

3  
 Pregnancy associated breast cancer
 [Sibylle Loibl]

1

3  
 Quality of life assessment: Fertility and pregnancy after breast
 cancer treatments
 [Fedro Peccatori]

1

3  
 Quality of life assessment: Sexuality and breast cancer treatment
 [Maria Die-Trill]

1

3  
 Quality of life assessment:
 Psycho-social problems and interventions
 
[Maria Die-Trill]

1

3  
 Optimizing adjuvant strategies: What about the patient’s
 perspective?
 [Susan Knox]
13  
 Follow-up schedule
 [Matti Aapro]
13  
 Module 5:

 Management of
 advanced breast
 cancer, male
 breast cancer
 and
 supportive
 therapies

 Scientific Directors: Nadia Harbeck, Olivia Pagani25

75

--

 Test (50q)

 Principles of multidisciplinary treatment
 [Nadia Harbeck]

26  
 The role of surgery
 [Maria Joao Cardoso]
13  
 The role of radiotherapy
 [Lotte Moser]
13  
 Principles of systemic therapy: Chemotherapy
 [Nadia Harbeck]
13  
 Principles of systemic therapy: Endocrine therapy
 [Olivia Pagani]
13  
 Principles of systemic therapy: Targeted therapies13  
 New compounds
 [Giuseppe Curigliano]
13  
 Management of young women
 [Ann Partridge]
13
  
 Management of elderly women
 [Laura Biganzoli]
13  
 Management of distinct sites of disease: Loco-regional relapse
 [Stefan Aebi]
13  
 Management of distinct sites of disease: Brain metastases1
3  
 Management of distinct sites of disease: Bone disease
 [Matti Aapro]
13  
 Management of distinct sites of disease: Liver metastases13  
 Management of oligometastatic disease
 [Christoph Thomssen]
13  
 Evaluation of treatment response:
 Response criteria and evaluation schedule
 
[Christoph Thomssen]
13  
 Symptoms’ control
 [Matti Aapro]
26  
 Supportive strategies: Physiotherapy13  
 Supportive strategies: Psychological support13  
 Supportive strategies: Social needs and interventions
 [Wendy W. T. Lam]
13  
 Supportive strategies: Complementary medicine13  
 Optimizing treatment of ABC:
 What about the patient’s perspective?
 [Shirley Mertz]
13  
 Male breast cancer
 [Fatima Cardoso]
2
6  

 Seminar 3:

 CCB

 Ulm,
 Germany


  
 
 
 Programme will follow



 

Examination regulations
(Module Tests and Certificate Examination)

At the end of each module participants have to pass a mandatory online test that has to be submitted to Ulm University. Only participants who passed the four tests will have access to the Certificate Exam at the end of the Programme.

Module Tests:

The written multiple-choice Module Test is deemed to have been passed if a minimum of 60% of the questions were answered correctly.

Module Tests are not graded and can be re-taken as often as necessary until the Test is passed.

Certificate Examination:

The Certificate Exam will be taken at Seminar 3 of the Programme.

The written multiple-choice Certificate Examination is deemed to have been passed if a minimum of 60% of
the questions were answered correctly. The grades are as follows:

1 = excellent, 90% or more;
2 = good, 80% or more but less than 90%;
3 = satisfactory, 70% or more but less than 80%;
4 = sufficient, 60% or more but less than 70%;
5 = insufficient, less than 60%.

The Examination is also deemed to have been passed if the number of questions answered correctly by the participant falls short of the average examination result for all first-time examinees for this examination by no more than 10% provided that the examinee answered a minimum of 50% of the questions correctly.

Failed Examination may be re-taken twice but only within the time of attendance of Seminar 3, or during the next Programme Seminar of the following cohort.